منابع مشابه
Bacterial surface proteins and vaccines
Surface-associated proteins play a key role in bacterial physiology and pathogenesis and are the major targets for vaccine development. Recent advances in defining the proteins associated with, and protruding out of, bacterial cells to a high level of accuracy are substantially contributing to accelerating the process of vaccine target identification and development.
متن کاملPlasmodium p25 and p28 surface proteins: potential transmission-blocking vaccines.
Plasmodium P25 and P28 Surface Proteins: Potential Transmission-Blocking Vaccines Ajay K. Saxena,* Yimin Wu, and David N. Garboczi School of Life Sciences, Jawaharlal Nehru University, New Mehrauli Road, New Delhi 110067, India; Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), 5640 Fishers Lane, Rockville, Ma...
متن کاملPurification Systems Based on Bacterial Surface Proteins
Affinity purification is based on the selective and reversible interaction between two binding partners, of which one is bound to a chromatography matrix and the other may be either a native target protein or a recombinant protein fused with an affinity tag (Cuatrecasas et al. 1968). Recombinant DNA-technology allows straightforward construction of gene fusions to provide fusion proteins with t...
متن کاملBacterial vaccines and antibiotic resistance
Spread of antibiotic resistance is mediated by clonal lineages of bacteria that besides being resistant also possess other properties promoting their success. Some vaccines already in use, such as the pneumococcal conjugate vaccines, have had an effect on these successful clones, but at the same time have allowed for the expansion and resistance evolution of previously minor clones not covered ...
متن کاملBacterial pathogen genomics and vaccines.
Infectious diseases remain a major cause of deaths and disabilities in the world, the majority of which are caused by bacteria. Although immunisation is the most cost effective and efficient means to control microbial diseases, vaccines are not yet available to prevent many major bacterial infections. Examples include dysentery (shigellosis), gonorrhoea, trachoma, gastric ulcers and cancer (Hel...
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ژورنال
عنوان ژورنال: F1000 Biology Reports
سال: 2010
ISSN: 1757-594X
DOI: 10.3410/b2-36